With higher strength and lower elastic modulus, it is more similar to human cortical bone, and has been used as a material for artificial hip joint and dental implant in clinical medicine in recent years. Long-term studies have shown that dense titanium alloy implants lack the ability to induce bone tissue growth, and their stability is poor due to the high density of the material. Therefore, some scholars pointed out that the porous structure material was used to replace the dense titanium alloy material.
Porous structural materials: Porous surfaces facilitate the growth of bone tissue and provide good biomorphic fixation. Studies have shown that bone tissue can infiltrate the porous materials, improve bone tissue connection with porous material, and porous materials can improve the biocompatibility of the material and tissue cells, improve the glass even protein and fibronectin in the alloy surface deposition, increase in cells on the surface of titanium alloy deposition, promote cell organization and the compatibility of porous materials.
Titanium-niobium alloy has high biomechanical strength and low elastic modulus, which is more similar to human cortical bone, and has been widely used as dental, orthopedic and artificial hip implant materials.
Objective: To observe the biomechanical strength and cytocompatibility of porous Titanium-niobium alloys with different porosity.
Methods: Porous Titanium-niobium alloys with 40% and 70% porosity were prepared by powder metallurgy. The pore size, elastic modulus and compressive strength of the two porous titanium-niobium alloys were measured. Rabbit bone marrow mesenchymal stem cells (BMSCS) were inoculated on porous ti-Nb alloy with 40% and 70% porosity respectively for 3, 24 and 72 h. Cell adhesion and proliferation were observed.
Results and CONCLUSIONS: (1) The pore size of porous Titanium-niobium alloy is 200-500 μm, and the two kinds are mainly 350 and 400 μm. The pore size of the porous titanium-niobium alloy is three dimensional connected. The surface of the material is rough. In the 40% porosity group, the pore distribution is not uniform and there is little connectivity between the pores. Both groups have higher compressive strength and lower elastic modulus, and there is no difference between the two groups. ② Both groups were beneficial to cell adhesion. The number of cell adhesion on the surface of 70% porosity group was more than that of 40% porosity group (P < 0.05), and extracellular matrix was formed on the surface of 70% porosity group. The results showed that 70% porous Titanium-niobium alloy was more beneficial to cell adhesion.
