The invention relates to a microalloyed Ti Zr Hf V Nb Ta refractory high entropy alloy and a preparation method thereof, belonging to the technical field of metal materials. The refractory high entropy alloy is mainly by adjusting the ratio of main components and adding a small amount of microalloying elements, so that the refractory high entropy alloy has good plasticity and high strength, and can adjust its density in a wide range; In addition, in the preparation process, high melting points hafnium, niobium, tantalum and other microalloying elements except Al are prealloyed and melted first, and then titanium, zirconium, vanadium and aluminium are added for final alloying and melting, which is beneficial to ensure the uniform mixing of several components with great differences in melting points, and ensure that the prepared refractory high entropy alloy has excellent comprehensive properties.
Bone is the scaffold of the human body, responsible for supporting, protecting, bearing, hematopoietic, calcium storage and other functions, is an important organization of the human body. Clinically, bone defects are often caused by trauma, infection, congenital defects and other reasons, which are the treatment problems faced by orthopedics every day. It is an ideal way to make artificial bones with artificial materials to fill the bone defects. Artificial bone is a substitute for human bone made of artificial materials. The ideal artificial bone should have good bone conduction, bone induction and bone formation. With the deepening of research on artificial bone, the function of artificial bone is not only to replace bone defects, but more to imitate the complex heterogeneous porous structure of human bone, thus increasing the bioactive surface area of artificial bone, so as to enhance the adhesion of osteoblasts and ensure the reliable long-term association with human bone. In order to improve the contact area between artificial bone and osteoblast, most of the existing artificial bones use porous scaffolds. The trabecular metal produced by Zimmer Company in the United States is a good example of this. However, in the existing porous scaffold structure of artificial bone, the pore structure of the scaffold is single, the pore size is fixed, and the pore of the scaffold is difficult to be completely connected, which leads to the great difference between the prepared artificial bone scaffold and human bone, poor biocompatibility, low biological activity, and difficult adhesion of osteoblasts. There are many typical manufacturing methods of artificial bone scaffolds: fiber bonding technology, particle leaching technology, gas foaming technology, phase separation technology. These methods all have certain defects :(I) in the manufacturing process, they all go through high temperature, high pressure or use organic solvents, which is very harmful to the biological activity; (2) controllable pore structures above 200μπιcan be difficult to shape; (3) It is difficult to ensure the complete penetration of pores; (4) It is difficult to realize the forming of multistage pore structure and material gradient structure with pore gradient; (5) It is difficult to realize personalized manufacturing.
Tantalum is non-cytotoxic and inert in vivo, with good biocompatibility and high biological activity. Its use history can be traced back to the mid-20th century, when many medical devices were made with this material, such as metal plates used in cranioplasty. At present, tantalum implants have been widely used in orthopedics, craniofacial and other aspects.
